A Potent Adaptogen, Eleuthero Previously Known as Siberian Ginseng
Similar to ginseng in many respects, Eleuthero, or Eleutherococcus senticosus, earned the name Siberian ginseng despite the fact that it is an entirely different genus than ginseng (although both are of the family Araliaceae).
While this name has been around for a long time, more people are beginning to use the actual name in short form, Eleuthero. Another lesser-known name, at least in Western countries, is Ciwujiia.
Known for its sweet, bitter and earthy taste, Eleuthero hails from the Acanthopanax species. Also called Eleutherococcus, Acanthopanax is a genus of 38 species of thorny shrubs and trees found in native Eastern Asia, southeast Siberia, Japan, the Philippines, and Vietnam.
Wide-Ranging Adaptogenic Benefits of Eleuthero
As an adaptogen, Eleuthero is non-toxic and produces a non-specific resistance to stress and fatigue on the cellular level and cause a normalizing effect on body systems. The term of ‘adaptogenic’ herbs was first coined by Russian scientist N.V. Lazarev in 1947, who used it to describe this non-specific effect that increases the body’s resistance to stress.
Some of the many benefits may include:
- Modulating Stress*
- Improving Memory*
- Improve Work Output*
- Help Building Blood*
- Improving Use of Oxygen*
- Supporting Immune Function*
- Mildly Stimulating*
- Increasing Retinal Sensitivity*
- May help with Insomnia*
- It even helped improve social life response in the elderly in one study!*
- Improving Endurance Output*
Some of the major identified components of Eleuthero include:
Two components, eleutheroside-B-1 and eleutheroside-E are known as androgenic substances. In a castrated rat study, eleuthero kept androgens at the same levels as before in other tissues even after the main source, the testicles had been removed.
In addition, it appears to shift the adrenal action from being cortisol towards DHEA.
Other herbs that fit the adaptogen definition are Ginseng, American Ginseng, Rhodiola Rosea, Ashwagandha and Schisandra Berry.
Eleuthero An Immune Booster
Eleuthero also contains complex polysaccharides (complex sugar molecules). These constituents may play a critical role in the herb’s ability to support immune function.
Your immune system is made up of many different types of cells all performing various functions to keep you healthy. These cells communicate by using cytokines, which are a group of proteins secreted by the cells of the immune system that act as chemical messengers.
Eleuthero has demonstrated the ability to influence cytokines levels, which may result in improved immune system function. Cytokines are molecules that play a central role in immune system responses. 
Eleuthero may either raises or reduces the levels of certain cytokines. 
Cytokines from one cell affect the actions of the other cells by binding to receptors on their surface. These receptors act like mailboxes, they receive the cell’s chemical message and then the receiving cell performs activities based on that message. 
In a study with rats that were forced to swim, Eleuthero increased their natural killer cell activity . A killer cell is a white blood cell that destroys infected or cancerous cells. Killer cells play a major role in eliminating viral infections.
Eleuthero Supports Mental Clarity and Focus
While not a true nootropic in the strict sense of the term, Eleuthero has been known to show cognitive benefits for its users.
Eleutherosides B and E have been reported to aid in learning and memory in experimentally aged rats.
A 4-week study on rats showed that rats who were introduced to Eleutherosides B and E at various doses showed increased acetyoclorine content and the regulation of enzyme expression (e.g. nitric oxide, superoxide dismutase, and NA+-K+-ATP. 
Rats introduced to eleutherosides B and E navigated a Morris water maze more effectively with fewer errors. 
The Power of Adaptogens for Stress Management
According to studies, the stress effect of adaptogens has been demonstrated on simple organisms and isolated cells. This may be due to the association with regulation and homeostasis of the neuro-endocrine-immune complex.
Eleuthero can ease stress by regulating the key mediators of stress response common to all cells. 
There are many ‘players’ when it comes to regulating our stress levels. These include heat shock proteins HSP70 and HSP16, FOXO, nitric oxide, JNK1, cortisol, glucocorticoid receptors (GR), Beta-endorphin, and the biosynthesis of ATP (energy providing molecules). 
JNK1 is a stress-activated enzyme that increases the formation of aggressive radicals and nitric oxide. This suppresses the generation of energy providing molecules (ATP) and causes many proteins not to work. It also increases cortisol levels. This leads to the first signs of fatigue and exhaustion. 
Heat shock protein (HSP70), on the other hand, enhances the repair of damaged proteins, inhibits the stress-induced function of nitric oxide genes, regulates ATP to normal levels, inhibits JNK, and activates GR and other mechanisms. 
Adaptogens, such as ADAPT-232 (a fixed combination of Rhodiola Rosa, Schisandra chinensis and Eleutherococcus senticosus extracts) decrease cortisol and JNK1 under stress and stimulate or activate the expression of HSP70 and p-FOX-01 (a protein involved in stress resistance, cell survival and longevity). The stimulation of HSP70 biosynthesis is a key point in the mechanism of adaptogens. 
Normal GR function and ATP levels are associated with anti-fatigue and anti-depression and with normal cognitive function (good attention, memory, and learning.) 
The Science of Keeping Yourself Cool, Calm and Collected
Eleuthero’s active constituents are called eleutherosides. It also contains triterpenoid saponins, polysaccharides, and glycans. 
Eleutherosides are a diverse group of chemical compounds. There are seven known Eleutherosides, including A, B, B1, B2, B3, B4, C, D, E1, E2, F, G, I, K, L and M. 
Eleutherosides B and E are the most important to humans when it comes to health benefits. Eleutheroside B is considered the most active constituent and is considered the most important part of the plant. It can be found in the bark from the woody stems.
Eleutherosides help reduce stress by supporting the adrenal gland. Located above the kidney, the adrenal gland reacts to stressors like illness or injury.
When you’re stressed, your body releases hormones such as cortisol and adrenaline to cope. If you’ve ever been in traffic and felt your skin tingle a bit, this is your body responding to stress.
The eleutherosides mediate the stress response while also keeping the brain alert. They do this without producing excessive adrenal hormones, which can leave us jittery or cold. Think coffee or amphetamines.
Eleuthero Is Great For Athletes
Behind the Iron Curtain, the Soviet Union was working hard to produce the best athletes. They knew of the benefits of ginseng but wanted to find a cheaper method of increasing their athlete’s abilities. Thus they came to use Eleuthero, and that is where its nickname comes from.
Dubbed ‘Siberian Ginseng,’ Eleuthero has been subjected to over 1,000 studies, making it one of the most closely observed herbs ever. When athletes started taking it as a supplement to their workout routine, the results were nothing short of miraculous. Most importantly, they flourished in times of great stress and tension. This is a trait anybody could benefit from, Olympian or not.
Studies on Eleuthero For Athletic Endurance & Recovery
Much research has been done in Russia and surrounding areas on this herb and its effects on endurance and recovery.*
A study done with six baseball players found an increased breathing capacity in just 8 days.*
In another study done in Australia 8 weeks of consuming Eleuthero led to 13% strength gains in the pecs and 15% in the biceps on average.*
One 8 week study found a 43% increase in the body’s ability to burn fat.*
Another 8-week study found a 12% increase in VO2 Max, a 23% endurance time increase, and a max heart rate increase of 4% over control groups.*
So you can see it may also help with endurance, breathing, strength gains and burning fat too!*
It’s important to note that not every study has shown positive effects from supplementation. For best results, we recommend a generous dose and at least 8 weeks to get the effects.
Buy Lost Empire Herbs Eleuthero
We’re excited to offer the highest quality Eleuthero possible. Our Eleuthero is wild harvested.
We process it by taking the raw roots through quality control and clean them. They are then extracted and concentrated with hot water and spray drying to arrive at a final powder, which is then packaged and shipped to you.
Take the Adaptogen Challenge!
Since adaptogens fall under the tonic family, they typically work more effectively the longer you take them. We recommend trying Eleuthero along with our other adaptogens (Rhodiola and Schisandra Berry) and see how your body responds. You can purchase all three herbs (plus cordyceps) as part of our Spartan Formula.
If you don’t feel the anti-stress effects from this herb after using it, please let us know and we’ll issue you a full refund.
Eleuthero Dosage and Usage Instructions
Since Eleuthero is in the tonic family, it’s best when taken over a long period of time.
The recommended dosage is 1-2 teaspoons per day and each bag should last you between 22 and 45 days. It can be taken any time of day. You can put it in coffee, tea or just eat it straight with a shot of water.
Eleuthero may cause interactions with blood pressure medication. Please consult your doctor before taking. Possible interactions with other medications may occur.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.