What is the real story on SHBG? As the name implies sex hormone-binding globulin (SHBG) is a globulin (a protein made up of about 400 amino acids) that binds to sex hormones which include testosterone, estrogen and more. It is the main component that is the difference between Total … [Read more...] about Sex Hormone Binding Globulin (SHBG): Good or Bad?